Inositol can prevent lung cancer in cigarette smokers

Cigarette smoking and reading the news of natural two completely incompatible concepts. Natural News readers, however, people in the end, and therefore not quite perfect. Furthermore, even the most fastidious raw foodist probably knows, or even those who sometimes likes to take a puff. For them, the study of substance, which appears on the back of harm to health consequences of smoking may have a ring of good news. Inositol, the connection is found in many foods, apparently to stop the threat of lung cancer from cigarettes dead in his tracks.

Inositol is a natural nutrient found in various forms, the most common of which is myo-inositol. Inositol is part of the B complex vitamins, although it is not officially recognized as a vitamin and RDA has been set. Like vitamins, it dissolves in water, and, consequently, not very well stored in the body. She needs constant replacement of the diet, although about 4 grams per day is produced from glucose in the kidneys.

Inositol is found in various foods such as nuts, seeds, oats, rice, beans, corn, chickpeas, liver, pork, veal, whole grains, cantaloupe, most citrus fruits, lecithin granules, and wheat germ. It is available as a supplement in capsule or powder form. Jarrow Formulas makes a powdered form that is easily available in the Internet-shop of health. There are others. Inositol powder delicious sweet, creamy taste and a fantastic addition to smoothies.

Two prominent researchers have found inositol prevents cancer

Dr. Lee was pleased, known as the "father of Prevention, searched for several decades starting from 1970` S, to find natural compounds that could theoretically prevent cancer, and then apply scientific methods of investigation of its opening. After testing several molecules, he found , inositol have great potential. Using different models of research he was able to demonstrate that inositol can prevent lung cancer. She was previously documented that poor nutrition has increased the chances of cancer happening, but Dr. Wattenberg was among the first to show that the total nutrient can actually prevent cancer, truly empowering discovery.

A few years after doctors were pleased, Dr. Abdul Kalam Shamsuddin, known as the "father of ip6 (IGF), have also shown that inositol could prevent cancer, demonstrating the preventive value of the connection with colon cancer. Research Dr. Shamsuddin has shown that inositol influences health in several ways, mainly because in all human cells and is one of the main components of cell membranes or linings, where it provides a link between the various organelles and molecules in a process known as cell signaling.

Why Don `T cigarette company's hand a bottle of inositol with each pack of cigarettes?

Some bright young executive at one of the major tobacco companies may have had the idea to increase sales, telling everyone that inositol, an inexpensive supplement to prevent lung cancer. But for the cigarette companies to buy into the idea, that would mean recognition of the fact that cigarettes cause cancer. Such recognition would create a huge legal liability for any company, production and sale of cigarettes.

Inositol provides many other benefits to the body

Inositol is an essential nutrient for hair growth. It helps prevent hardening of the arteries and plays an important role in the formation of lecithin and the metabolism of fats and cholesterol. This helps remove fat from the liver. Inositol has a calming effect on the brain and successfully applied in large doses in the treatment of mental disorders such as depression, bipolar, obsessive-compulsive and panic. Inositol is also used for insomnia, retinopathy, anorexia and bulimia and Binge Eating. This is useful for diabetic neuropathy, brain seizures, as well as to normalize cholesterol and triglyceride levels.

Symptoms of deficiency atherosclerosis, constipation, hair loss, high blood cholesterol, irritability, mood swings, and skin eruptions. Consumption of large quantities of caffeine usually leads to a deficiency of inositol. As the consumption of coffee is often accompanied by smoking, the lack of inositol may have been a major factor in the case of smoking-induced lung cancer is so prevalent in the period when smoking was in style.

Research continues to refine the knowledge of the mechanisms by which inositol works

Being a natural compound, there is little incentive for pharmaceutical companies to study inositol. Natural compounds can not be patented. However, some researchers dedicated to continue to examine the effects of inositol, trying to identify the specific mechanisms by which it prevents lung cancer in smokers. Here are brief abstracts of the most recent research. It is truly amazing, and may be criminal is a better word, that the smoking public was not informed of these results, which date from the stable by the time the doctor. Watterberg and Shamsuddin.

The results

Phosphatidyl inositol 3-kinase-akt way becomes an important regulator of tumor cell survival. Substances that prevent this path, have great potential in the treatment of cancer. In Biochemical Pharmacology, December 2008, the researchers report myo-inositol strengthen the corresponding cell death. This effect is associated with down regulation of various gene products that mediate cell survival, proliferation, metastasis, and invasion, all known to be regulated by NF-kappaB. Inositol compounds blocked NF-kappaB activation induced by cigarette smoke.

Cancer Epidemiology Biomarkers and Prevention in August 2006, reported a clinical study conducted to evaluate the safety, tolerability, maximum tolerated dose, and the potential chemopreventive effects of myo-inositol in smokers with bronchial abnormal cell development. Smokers aged 40 to 74 participated in the dose escalation from 12 to 30 grams per day of myo-inositol per month to determine the maximum tolerated dose, which was 18 grams per day. Ten new subjects were then enrolled to take the maximum tolerated dose for 3 months. Side effects, if present, were mild and mainly gastrointestinal nature. Significant reduction rate of abnormal cells was not observed (91% compared with 48% in the control group). A significant reduction in systolic and diastolic blood pressure by an average of 10 mm Hg were observed after taking 18 grams of inositol per day for a month or more.

Researchers reported that smoking is a major risk factor for cardiovascular disease. Nicotine has been shown to modify gene expression. In a study reported in physiological genomics, April 2001, researchers tried to identify the various ways through which the modified genes through. They noted the expression of more than 4000 genes of human coronary artery endothelial cells and identified a number of nicotine-modulated genes encoding proteins involved in signal transduction or transcription regulation. Among them are genes that regulate inositol phospholipids way.

Journal of Experimental lung research, December 2000, reported a mouse undergoing the impact of a body for 6 hours per day, 5 days a week for 5 months to a mixture of primary side and cigarette smoke, and then kept for another 4 months in a controlled air environment, especially than scored for lung tumors. In 7 independent experiments, the number of lung tumors was significantly increased in each experiment, and the incidence of lung tumors was increased in 5 experiments. Several compounds were evaluated for their ability against these tumors, but none of them reduce the incidence of lung tumor or multiplicity. Nevertheless, dietary mixture of myo-inositol and dexamethasone (synthetic steroid hormones that act as anti-inflammatory and immune system suppression) was effective in reducing the incidence of lung tumor multiplicity and compared with the control. This effect was also seen when animals were fed myo-inolitol-dexamethasone mixture, when they were removed from the smoke. The researchers concluded that people who have recently quit smoking might benefit from this connection.

Researchers have recognized that chronic effects on rats and mice to cigarette smoke affects T-cell responses that may explain the decreased T-cell proliferation, T-dependent antibody responses in humans and animals exposed to cigarette smoke. In a study reported in the Journal of Pharmacology and Experimental Therapy, April, 2000, researchers tried to discover the mechanism by which cigarette smoke affects the function of T cells. They found that spleen cells from animals with chronic nicotine exhausted inositol stores and decreased ability to increase the level of intracellular calcium. Their results show that smoking causes a chronic T-cell energy and reduce damage from lack of ways and depletion of inositol is stored in the resulting decreased levels of inositol-sensitive calcium.

Mice were fed a diet supplemented with myo-inositol and exposed for 5 months on a mixture of side and smoke cigarettes mainly in the study reported in carcinogenesis, July 1999. Animals were fed only control diet, the average number of overt lung tumor 2.1. In animals given the control diet plus inositol mixture, the number of overt lung tumors was 1.0. Researchers concluded that the mixture is an effective treatment to prevent early tobacco-induced lung tumors.

In a study reported in the Journal of Immunology, April 1996, as the T-and B-lymphocytes from animals chronically treated with nicotine exhibited decreased ability to mobilize intracellular calcium and the inability to complete the cell cycle. Nicotine treated cells significantly lost their ability to up-regulate the synthesis of inositol. This reaction continues for at least 2 weeks after cessation of nicotine treatment. The researchers concluded that chronic IN VIVO effects of nicotine leads to T-cell loss of energy and activity and can lead to nicotine / cigarette smoke-induced suppression of the immune system.